TRANSFAC Workspace
The most comprehensive transcription-factor resource — now one complete workspace for gene regulation, signalling networks and disease and drug discovery.
>10,000
Positional weight matrices
>1M
Experimental TF sites
>1.2M
Curated reactions
>1,500
Pathways
>140,000
Biomarkers
>55,000
Drug targets
The reference knowledge base for eukaryotic gene regulation
TRANSFAC is the gold-standard database of eukaryotic transcription factors, their binding sites and DNA-binding models — manually curated, experimentally validated, and integrated with 200+ analysis tools.
Whether you explore gene regulation, reconstruct signalling networks or hunt disease biomarkers, the knowledge base and the tools live in one place.
One workspace for the complete regulatory journey
A list of genes is rarely the answer. TRANSFAC Workspace connects the layers you actually have to move through.
Gene regulation Transcription factors Signalling & metabolic pathways Master regulators Disease mechanisms Biomarkers & drug targets
From a list of genes to the mechanisms and targets behind them
Regulation is hidden in the genome
Binding sites, their combinations and the promoters and enhancers that control your genes are scattered and buried in the literature.
Signals span whole networks
Understanding a gene means reconstructing the cascades upstream of its regulators, across millions of reactions.
Translation demands integration
Turning findings into targets and biomarkers means joining regulation, pathways and disease in one place.
Three domains of analysis, one workflow
From raw data to a paper-ready report, in one platform
01
Bring your data
Start from a gene, a sequence, a list of differentially expressed genes, variants or multi-omics data.
02
Find binding sites
Locate the transcription-factor binding sites and the regulatory elements that control your genes.
03
Reconstruct networks
Trace the signalling and metabolic cascades and rank the master regulators that drive them.
04
Translate to disease
Move from mechanism to biomarkers and prospective drug targets, with a one-click report at the end.
From the bench to the command line
No coding required
Guided, no-code workflows so a biologist gets to the answer without writing a line of code.
Full control and the API
A documented API and scripting for teams that want to automate and integrate it into their own pipelines.
The gold standard, by construction
Manually curated
Every entry read and entered by hand, not imported in bulk.
Experimentally validated
Binding sites and reactions backed by the experiment behind them.
Broad and deep
Regulation, signalling and disease, joined across one knowledge base.
Continuously updated
Two curated releases every year, with documented change notes.
The four asked most often
No. The workspace is fully no-code, with guided workflows; a documented API is there for teams that want to automate.
TRANSFAC, TRANSPATH and HumanPSD are updated on a fixed release cycle, twice a year, each with change notes.
The knowledge is manually curated and experimentally validated, and it is integrated with the tools that analyse it.
Yes — genes, regulatory sequences, differential-expression lists, genomic variants or multi-omics data.
Three ways in, one body of knowledge
Maximise your potential with the gold standard
Tell us your scale — experiments, seats, storage, usage time — and we will build the package around you.