TRANSFAC 2.0 · the gold standard

TRANSFAC Workspace

The most comprehensive transcription-factor resource — now one complete workspace for gene regulation, signalling networks and disease and drug discovery.

>10,000

Positional weight matrices

>1M

Experimental TF sites

>1.2M

Curated reactions

>1,500

Pathways

>140,000

Biomarkers

>55,000

Drug targets

The gold standard

The reference knowledge base for eukaryotic gene regulation

TRANSFAC is the gold-standard database of eukaryotic transcription factors, their binding sites and DNA-binding models — manually curated, experimentally validated, and integrated with 200+ analysis tools.

Whether you explore gene regulation, reconstruct signalling networks or hunt disease biomarkers, the knowledge base and the tools live in one place.

One workspace for the complete regulatory journey

A list of genes is rarely the answer. TRANSFAC Workspace connects the layers you actually have to move through.

Which transcription factors regulate your genes

Where the binding sites, promoters and enhancers are

Which factor combinations may be active

Which signalling pathways control those factors

Which upstream molecules act as master regulators

Which mechanisms and biomarkers point to a target

Gene regulation Transcription factors Signalling & metabolic pathways Master regulators Disease mechanisms Biomarkers & drug targets

Why researchers need it

From a list of genes to the mechanisms and targets behind them

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Regulation is hidden in the genome

Binding sites, their combinations and the promoters and enhancers that control your genes are scattered and buried in the literature.

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Signals span whole networks

Understanding a gene means reconstructing the cascades upstream of its regulators, across millions of reactions.

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Translation demands integration

Turning findings into targets and biomarkers means joining regulation, pathways and disease in one place.

Three domains of analysis, one workflow

Gene regulation

Discover TF binding sites in the promoters and enhancers of your genes.

Binding sites & PWMs

Promoter and enhancer analysis

What ships

Signalling networks

Reconstruct the signal-transduction network controlling your genes.

1.2M curated reactions

Master-regulator search

What ships

Disease & targets

Identify drug targets and disease biomarkers, even for complex clinical cases.

Disease models & biomarkers

Druggable control points

What ships

How it works

From raw data to a paper-ready report, in one platform

01

Bring your data

Start from a gene, a sequence, a list of differentially expressed genes, variants or multi-omics data.

02

Find binding sites

Locate the transcription-factor binding sites and the regulatory elements that control your genes.

03

Reconstruct networks

Trace the signalling and metabolic cascades and rank the master regulators that drive them.

04

Translate to disease

Move from mechanism to biomarkers and prospective drug targets, with a one-click report at the end.

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How cancer cells outsmart therapy

A worked case: HER2-positive breast-cancer trastuzumab resistance, traced from altered genes through the regulators and pathways to the control points that explain the escape.

Mechanism reconstructed end to end

Master regulators ranked

Druggable points identified

Read the case

Built for the whole lab

From the bench to the command line

No coding required

Guided, no-code workflows so a biologist gets to the answer without writing a line of code.

Full control and the API

A documented API and scripting for teams that want to automate and integrate it into their own pipelines.

The gold standard, by construction

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Manually curated

Every entry read and entered by hand, not imported in bulk.

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Experimentally validated

Binding sites and reactions backed by the experiment behind them.

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Broad and deep

Regulation, signalling and disease, joined across one knowledge base.

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Continuously updated

Two curated releases every year, with documented change notes.

Questions, answered

The four asked most often

No. The workspace is fully no-code, with guided workflows; a documented API is there for teams that want to automate.

TRANSFAC, TRANSPATH and HumanPSD are updated on a fixed release cycle, twice a year, each with change notes.

The knowledge is manually curated and experimentally validated, and it is integrated with the tools that analyse it.

Yes — genes, regulatory sequences, differential-expression lists, genomic variants or multi-omics data.

Explore the platform

Three ways in, one body of knowledge

TRANSFAC Services

Give us the target or disease; our scientists deliver the answer.

Open

TRANSFAC Knowledge Graph

License 38+ years of curated biology as data, to ground your own AI.

Open

Overview

See all three ways in and pick the one that fits your team.

Open

Maximise your potential with the gold standard

Tell us your scale — experiments, seats, storage, usage time — and we will build the package around you.