Design system

GX component catalog

Every component the site can be built from, rendered by the same code that builds real pages. FOUND means it already exists on genexplain.com, rewritten in Diana’s palette; ADDED means it is proposed to complete the system.

How to read this

75 components in 14 groups — 28 found on the site, 47 proposed. Each specimen shows the component as it would appear in a page; the grey line under its name says when to reach for it.

Contents

Foundations

Page structure

Content

Value card  ·  Product card  ·  Package card  ·  Package card, wide  ·  Card on a dark ground  ·  Numbered stack  ·  Split feature  ·  Feature grid  ·  Punchline inset  ·  Spec rows  ·  Check list  ·  Pill row  ·  Prose columns

Data

Stat grid  ·  Metric tile  ·  Comparison pair  ·  Data table

Status

Notice  ·  Badge  ·  Steps

Navigation

Anchor nav  ·  Index tiles  ·  Breadcrumbs  ·  Previous / next

Media and people

Media card  ·  Resource item  ·  Logo row  ·  Person card  ·  Pull quote

Commerce

Pricing card  ·  Add-on card  ·  Split panel  ·  Split accordion  ·  Testimonial card  ·  Logo wall

Native blocks

Icon list  ·  Tabs

Articles

Article header  ·  Post card  ·  Author bio  ·  Figure  ·  Pagination

Publications and events

Behaviour

Modal  ·  Video popup  ·  Disclosure  ·  Countdown  ·  Gallery

From the reference systems

Banner  ·  Page header  ·  Code  ·  Glossary term  ·  Progress steps  ·  Task list

Reference

Timeline  ·  FAQ accordion  ·  References

Group · 4 components

Foundations

The decided values. Everything else is assembled from these — and the reason the live site looks inconsistent is that it currently carries fifteen radii, twenty-five border colours and eighty-four backgrounds.

Product colour

FOUND

Three sub-brands, three hues. This is the important constraint on the whole system: on this site colour already means which product. That is why status further down cannot borrow orange or green.

TRANSFAC · #1C75BC

BRENDA · #F19057

CHEMO · #97B63D

Contents

TRANSFAC ramp

FOUND

Eight shades from Diana’s gradient guide, plus the tf-100 tint that sits outside the ramp and does most of the surface work.

tf-900

tf-800

tf-700

tf-600

tf-500

tf-400

tf-300

tf-200

tf-100

white

Contents

Text roles

FOUND

Six roles, no more. The two eyebrow classes must never merge: the section marker is navigation, the sub-marker is a quiet caption inside level-2 structure.

Section marker · 15 / 2.1 / uppercase

Heading 2 · 36 / 600 / measure 880

Sub-marker · 12 / 1.68 / ink-3

Lead paragraph · 17px, measure 760. Carries the section’s promise.

Body · 16px, line height 1.6. The proof for the slow reader.

Caption · 14px italic, ink-3. Footnotes and provenance.

Contents

Radius, hairline, surface

FOUND

Three radii only — 8 for controls, 12 for cards, 16 for card shells. One hairline colour on light, one on dark.

Radius

8 controls · 12 cards · 16 shells

Hairline

rgba(28,117,188,0.14)

Card border

rgba(28,117,188,0.18)

Surfaces

#ffffff · #edf5fc tint · #001a2e dark

Section padding

88 desktop / 72 tablet / 56 mobile, with side gutters

Contents

Group · 11 components

Page structure

The frame of a page: how it opens, how sections are announced, how it closes.

Hero · blue

ADDED

Deepest of the three tones, and the only one that carries white text. Colours and 48.5° angle are Diana’s own, from the banners in Visual library/A; the light stop is held past the frame so a narrow phone hero cannot pull it into the text. Campaign and landing pages.

Release 2026.1

Grounded biological data

38 years of manually curated transcriptional regulation, licensed as one database.

Hero · mid

ADDED

The middle regime: ink text, never white. Its lead is ink rather than ink-2 — ink-2 measures 4.49 on the saturated end and does not pass. Section fronts and hubs.

Release 2026.1

Release announcement

TRANSFAC, TRANSPATH and HumanPSD databases release 2026.1, geneXplain platform 7.8 and Genome Enhancer 3.8.

Published June 2026 · 12 changes across 5 products

Hero · white

ADDED

The quietest tone, and the only one where every text role works unchanged. Reference and documentation pages read better light — a dark band signals campaign, and makes a changelog feel like a pitch.

Release 2026.1

Release announcement

TRANSFAC, TRANSPATH and HumanPSD databases release 2026.1, geneXplain platform 7.8 and Genome Enhancer 3.8.

Published June 2026 · 12 changes across 5 products

Hero · blue mirrored

ADDED

Every tone takes side=”left”, which flips gradient and pattern together. This is a trap as much as an option: with a left-aligned heading the busy corner lands under the words, which is the arrangement Diana’s banners avoid. The mirrored set is for centred layouts, and is shown centred here.

Release 2026.1

Grounded biological data

38 years of manually curated transcriptional regulation, licensed as one database.

Hero · mid mirrored

ADDED

The middle tone with the pattern on the left. Same ink text rules as its upright twin.

Release 2026.1

Release announcement

TRANSFAC, TRANSPATH and HumanPSD databases release 2026.1, geneXplain platform 7.8 and Genome Enhancer 3.8.

Published June 2026 · 12 changes across 5 products

Hero · white mirrored

ADDED

The quietest tone mirrored. The pattern is faintest here, so this is the one where the mirrored arrangement costs least.

Release 2026.1

Release announcement

TRANSFAC, TRANSPATH and HumanPSD databases release 2026.1, geneXplain platform 7.8 and Genome Enhancer 3.8.

Published June 2026 · 12 changes across 5 products

Section header

FOUND

The fixed opening of every section: eyebrow, H2, lead. Only the H2 is required — pass no eyebrow where the section needs no navigation marker, and no lead where the heading already says everything. Measured reason it exists: across the block markup of 194 live pages there are 35 different heading colours, and the most used one, #9ba0a6 at 222 occurrences, measures 2.63:1 and fails contrast.

What’s inside

Three curated layers. One licensed database.

Everything that ships with a license, and nothing that does not.

The same header with no eyebrow

For a page with one section, or the first section under a hero that already said where the reader is.

Contents

Subsection header

ADDED

The same opening one level down, for splitting a long section. The site already needs it: 625 h3 across 194 pages, three quarters as many as h2 — and not one of them carries a size, 520 carry no colour, so h3 is the one heading nobody ever styled. 26px sits clearly between the 36px section H2 above and the 19px card title inside. The hairline above it does the real work: a heading one step smaller is easy to scroll past, a rule the reader crosses is not. There is deliberately no fourth level. Only 20 of 194 live pages use three heading levels at all, and the h4s that exist say things like “Step 1” and “How to cite PASS:” — items in sequences and lists, already covered by steps, numbered stack, feature grid and spec rows. A fourth level would also land at ~21px, where the card title already is.

Part one

With a marker and a lead

The lead drops to 16px here, one step under the section lead, so the two are never mistaken for each other.

Bare form, heading only

Contents

Manifest reveal

FOUND

A dark breather between argument blocks. Names the alternative in one word and moves the reader from ‘saw the problem’ to ‘here comes the answer’. Once per page.

The stakes

Grounded.

Curated mechanism, traceable to the experiment that produced it — not co-expression that happens to agree.

CTA band

FOUND

Pages close the way they open, in the same three tones as the heroes and the manifest. Previously two hand-built variants that did not belong to the same family: a dark one with its own radial gradient, and a light one that was a flat tint with neither gradient nor pattern. Padding also differed, 110 against 72, for no stated reason — one number now. Unlike the manifest there is no rule against matching the section above: a manifest interrupts, so sameness kills it, while a CTA concludes, and continuing the surface it concludes from is a legitimate quiet ending.

Interested in licensing our products?

Find out the prices for the products of your interest.

CTA band — white

FOUND

The quiet close, for reference pages that should not end on a heavy note.

Interested in licensing our products?

Find out the prices for the products of your interest.

Group · 13 components

Content

The blocks an argument is actually made of. Everything here sits inside a section, under a section header, and none of it is full-bleed.

Value card

FOUND

One shape, four slots. Counted over the block markup of the 194 live pages: of 170 card-like structures, 63 are title-and-text, 47 carry a list inside and 56 carry a link out — so list and link are slots, not separate components. Equal height comes from putting the surface on the column, not on a rowlayout nested inside it: columnsInnerHeight stretches columns but never their contents, so nested cards read 117/141/165 where these read 165/165/165. The live site fakes it with minHeight, which holds only until some text is longer than the number. The column count is chosen from the item count — four cards go two-by-two rather than three-plus-an-orphan.

Plain

Title and text. The 63-case majority.

With a chip

A short qualifier under the text.

Included

With a list

Points that have to be enumerated.

First inclusion

Second inclusion

With a link

A card that leads somewhere.

See the detail

List and link

Both slots, the 34-case pattern.

First inclusion

Second inclusion

See the detail

Sixth

Six divides by three, so no stub row.

Four cards — two by two, not three plus one

One

Short.

Two

A longer body so the heights would differ if the surface sat on a nested rowlayout.

Three

Short.

Four

Short.

Contents

Product card

ADDED

A cross-reference: this thing belongs to product X, go there. Hue on the left edge is the honest home for BRENDA orange and CHEMO green — on this site colour already means which product, which is exactly why status cannot borrow it. No picture and no call to action; it points, it does not sell. The hue says which product; it does not say where the card ends. This card used to carry its own surface, which cost it twice — nested, so the row rendered 173/197/173, and white on white, so the only boundary was a hue measuring 2.37:1 for BRENDA and 2.31:1 for CHEMO against a 3.0 threshold. The surface now comes from the grid and the stripe stays the brand colour.

TRANSFAC® 2.0

Transcription factors, binding sites and PWMs.

Open TRANSFAC

BRENDA

Search the comprehensive enzyme information system.

Open BRENDA

Chemo-Informatics

PASS, GUSAR and PharmaExpert, for activity and toxicity.

Open the cluster

Contents

Package card

ADDED

A different job from the card above: this one sells. Measured on the live site — the “Request price” call appears on ten pages and 34 times on the pricing page alone, always in the same shape. The head is dark because the screenshots are. The blue field baked into those files takes 57%, 36% and 47% of the three used on the home page, so a light card put a heavy slab above unbounded white text; the card adopts that blue instead of fighting it. Cropping at 21:9 rather than 4:3 drops the field to 33/15/29%. One action, not two — a ghost link beside the button competed with it for the same click.

TRANSFAC search results listing binding sites for a query gene
TRANSFAC

Basic

Discover TF binding sites in promoters and enhancers of your genes.

A signalling pathway drawn as a network of reactions in TRANSPATH
TRANSFAC

Pathways

Reconstruct the signal transduction network controlling your genes.

Disease associations for a transcription factor, shown as a ranked table
TRANSFAC

Diseases

Identify drug targets and disease biomarkers from the literature.

Contents

Package card, wide

ADDED

The same card lying down, one to a row, when the screenshot is worth reading rather than glancing at. The picture is a column background, not an image block: a ratio-cropped image is sized by its own aspect and left 16px of card showing under it whenever the words ran taller, while a cover background fills its half at any height. The cost is real — a background carries no alt text, so here the picture is decorative and the words carry the meaning alone.

TRANSFAC

Basic

Discover TF binding sites in promoters and enhancers of your genes, and compare them against matrices built from the literature.

TRANSFAC

Pathways

Reconstruct the signal transduction network controlling your genes, then rank the master regulators that drive it.

Contents

Card on a dark ground

ADDED

The same card three times, on each of the three surfaces. A card must never take the fill of the ground under it. Measured after making that mistake in both directions: a tinted card on the tint section rendered 1.00:1 and a white card on the white section rendered 1.00:1 — the same colour, no edge at all. So the fill alternates and callers do not choose it. On the dark ground the border earns its place: the card’s head starts at rgb(15,59,94) where the section passes through rgb(0,59,97), which is 1.01:1, so without a border the top of the card dissolves while its body still reads at 6.81–16.06:1.

TRANSFAC search results listing binding sites for a query gene
TRANSFAC

Basic

Discover TF binding sites in promoters and enhancers of your genes.

A signalling pathway drawn as a network of reactions in TRANSPATH
TRANSFAC

Pathways

Reconstruct the signal transduction network controlling your genes.

Disease associations for a transcription factor, shown as a ranked table
TRANSFAC

Diseases

Identify drug targets and disease biomarkers from the literature.

Contents

Numbered stack

FOUND

An ordered argument where each step earns the next. Numerals stay quiet through size and weight rather than through pale colour, which fails contrast.

01

Public data is built for exploration

It is assembled to be browsed, not depended on by a model in production.

02

The grammar has to be verified

Every reaction carries the experiment it came from, so a claim can be traced.

03

Cost is measured in years

In drug discovery the price of the wrong grammar is not a bad quarter.

Contents

Split feature

ADDED

Image one side, argument the other, alternating down the page. Alternating sides is what stops a long page reading as a list.

Gx Icon Transpath V2

Mechanism, not correlation

Curated causal reactions instead of co-expression that happens to agree, each traceable to the experiment that produced it.

1.2M signal transduction reactions

1,631 curated pathways

Every reaction carries its source

See what ships

Contents

Feature grid

ADDED

Icon, title, one line. For capability lists where a value card is too heavy and a bullet list too flat.

Gx Icon Transfac V2

Binding sites

118,987 experimentally verified sites.

Gx Icon Transpath V2

Causal reactions

Signal transduction, not correlation.

Gx Icon Humanpsd V2

Clinical evidence

1.4M drug–disease–trial links.

Gx Icon Platform V2

No coding

200+ tools behind one interface.

Gx Icon Genome Enhancer V2

One click

Raw multi-omics to drug targets.

Quarterly releases

Two database releases every year.

Contents

Punchline inset

FOUND

The one line in a block that should land. Once per section at most — a page of punchlines has none.

Public databases are not bad. They are insufficient for grounded AI.

Contents

Spec rows

FOUND

Sparse, text-only inventories. Beats a card grid when items have no icons or numbers, and unlike a card row it does not leave a hole at five items.

Data

TRANSFAC, TRANSPATH and HumanPSD, full release

Tools

MATCH Suite, Pathfinder, genome browser

Service

Quarterly updates, curation support, licence review

Contents

Check list

FOUND

Included and excluded. iconVerticalAlign baseline belongs on every item, not only the visibly multi-line ones, or icons drift as the copy changes.

Full database dump under licence

Quarterly release with change notes

Named curation contact

Contents

Pill row

FOUND

A run of short tags. One heading block, N marks — they wrap by themselves. fontHeight 3 is load-bearing: mark padding escapes the line box and rows collide below it.

Transcription factors Binding sites PWMs Enhancers Composite modules ChIP fragments

Contents

Prose columns

ADDED

Long-form text in two measures. Past roughly 90 characters a line gets hard to track back to; splitting is cheaper than shortening approved copy.

The geneXplain platform brings together more than two hundred analysis tools behind a single interface, so a study can move from raw reads to a ranked list of regulators without leaving the environment or writing code.

Every database release is curated by hand rather than imported. That is slower, and it is the reason a claim in TRANSPATH can be traced to the experiment that produced it rather than to a correlation that happened to hold.

Contents

Group · 4 components

Data

Blocks that carry numbers.

Stat grid

FOUND

Figures that frame a product. Flush cells with partial borders, so every internal edge is exactly 1px and no joint doubles up.

12,469

DNA motifs across all taxa

118,987

Experimentally verified binding sites

>1.2M

Signal transduction reactions

1,631

Pathways

>1.4M

Drug–disease–trial links

802,036

Biomarker annotations

Contents

Metric tile

ADDED

A figure that moved. The site shows plenty of numbers but never shows change, which is most of what a release note is actually about.

New PWMs

1,346

+1,346 this release
New reactions

13,942

+7,250 publications
Disease annotations

443,444

+25,217 since 2025.2

Contents

Comparison pair

FOUND

Two positions side by side. A table earns its place at ten rows or more — four points against four is two cards.

A general bioinformatics CRO

Runs the analysis you specify

Public databases as the substrate

Correlation-level conclusions

You interpret the output

TRANSFAC Solutions

Scopes the question with you

38 years of manual curation

Causal mechanism, traced to experiments

You get a ranked decision

Contents

Data table

ADDED

A real table, for the case the rule allows: ten rows or more and genuinely tabular. On a phone Kadence wraps it in a scroll region with no keyboard access, which axe reports as a serious failure — so prefer spec rows whenever the data can carry it.

Database

Release

Records

Updated

TRANSFAC®

2026.1

50,950 factors

June 2026

TRANSPATH®

2026.1

1,267,686 reactions

June 2026

HumanPSD™

2026.1

443,444 annotations

June 2026

Protein Genome Map

2025.2

234,192 PTM sites

December 2025

TRANSFAC® matrices

2026.1

12,469 motifs

June 2026

Enhancers

2026.1

231,413 entries

June 2026

Composite elements

2026.1

593 elements

June 2026

Pathways

2026.1

1,631 pathways

June 2026

Molecules

2026.1

1,110,422 molecules

June 2026

Clinical trials

2026.1

1,455,913 links

June 2026

Contents

Group · 3 components

Status

Blocks that say what changed — without borrowing a product’s colour.

Notice

ADDED

Four tones. Note what is not here: green and orange. Two of the three brand hues name products, so a green success box would read as Chemo Informatics and an orange warning as BRENDA. Status is carried by icon and label instead, with one coloured exception — alert red, which no product owns.

Database updated

TRANSFAC, TRANSPATH and HumanPSD move to release 2026.1 in this cycle.

Backwards compatible

Existing workflows run unchanged; results may differ where data was corrected.

Editorial note

Figures in this section are pending confirmation from the product team.

Analysis results may vary

With the new release, results can differ from those produced by earlier versions.

Contents

Badge

ADDED

Status on a heading or a list row, deliberately hue-free apart from the blue — which is the site’s system colour rather than any one product’s, since TRANSFAC, TRANSPATH and HumanPSD all wear it.

New
Updated
Beta
Deprecated
Breaking

Contents

Steps

ADDED

An ordered process across cards. Built by hand on Solutions; as a component it stops being re-invented on every page.

Step 1

Low starting fee

You bring the target or disease. We scope the work.

Step 2

Pay on success

The rest falls due when your targets validate.

Step 3

Full package

Translational development, scoped case by case.

Contents

Anchor nav

ADDED

A compact jump rail. Different job from the index tiles: tiles are a contents list you read, this is a rail you skim. It cannot be made sticky from page content — Kadence ignores isSticky, sticky and position on a rowlayout. The sticky sub-nav on /knowledge-graph/ is a Kadence Header post, and that route is reachable through the API if we want it.

Why grounding

What’s inside

Curated vs public

Track record

Index tiles

FOUND

A table of contents at the top of a long page. Padding sits on the link, not the column, or the tap target is only as tall as the text — 22px against a 44px floor.

Contents

Breadcrumbs

ADDED

Nothing on the site tells a visitor where they are. This is half of why the release pages read as orphans.

HomeReleasesRelease 2026.1

Contents

Previous / next

FOUND

Without it every page is a dead end. Applies to releases, blog posts and any ordered series.

Contents

Group · 5 components

Media and people

Blocks that carry images, files and faces.

Media card

ADDED

Image over text. There is no reusable article or resource card today, so every listing is rebuilt from scratch.

Gx Icon Transfac V2

Grounding foundation models

What a curated regulatory graph changes about model output.

Read more

Gx Icon Transpath V2

Mechanism over correlation

Why causal reactions beat co-expression for target ranking.

Read more

Gx Icon Humanpsd V2

From biomarker to trial

Tracing a marker through disease annotation into clinical evidence.

Read more

Contents

Resource item

ADDED

A downloadable with its type and size stated. Release pages currently link PDFs as bare inline text, which gives no signal about what is about to open.

TRANSFAC® 2026.1 — database statistics

PDF · 125 KB

TRANSPATH® 2026.1 — database statistics

PDF · 111 KB

PROTEOME 2026.1 — database statistics

PDF · 145 KB

Contents

Logo row

ADDED

A product or trusted-by strip. Assembled ad hoc on several pages today, with a different alignment each time.

Gx Icon Transfac V2
Gx Icon Transpath V2
Gx Icon Humanpsd V2
Gx Icon Platform V2
Gx Icon Genome Enhancer V2

Contents

Person card

FOUND

A named human attached to a claim. maskSvg circle works on any source aspect ratio, unlike a radius plus an overflow wrapper.

Dr. Alexander Kel CEO And CSO

Prof. Dr. Alexander Kel

CEO & CSO, co-author of TRANSFAC®

Bring your specific question. We will tell you whether the database fits.

Contents

Pull quote

FOUND

An attributed statement that carries weight. 72/28 so the plate is never narrower than its column, which is what made an earlier version read as a layout bug.

“A model can generate a conclusion. It cannot take responsibility for one.”

Prof. Dr. Alexander Kel

CEO & CSO, co-author of TRANSFAC®

Dr. Alexander Kel CEO And CSO

Contents

Group · 6 components

Commerce

Rebuilt from patterns on kinsta.com. Kinsta runs WordPress on a bespoke theme, not Kadence, so nothing could be lifted — these are their arrangements observed and rebuilt in Diana’s palette, which is the only form in which they are any use to us. They fill the gap the site has around licensing and pricing.

Pricing card

ADDED

Plan, price, what you get, one action. Licence tiers are prose on the site today. A price needs its unit beside it or the number is unreadable, and one card in a row should be visually ahead or the eye has nowhere to land first.

Controlled AI Licence

€24,000

per year

Full database under licence

On-premise deployment

Quarterly releases included

Named curation contact

AI & Externalisation

€48,000

per year

Everything in Controlled

Model externalisation rights

Derived-data provisions

Priority curation support

Disease area slice

from €9,000 €12,000

per year

One disease area

Scoped to your programme

Upgrade credit to full licence

Quarterly releases included

Contents

Add-on card

ADDED

A secondary purchase: what it is, then what it costs. Takes several rates in one card, so an option priced two ways does not become two cards.

Additional disease area

Extend an existing licence to a second indication without renegotiating the base agreement.

€6,000

per area / year

Curation on request

Targeted manual curation of a pathway or factor family, delivered into your licensed release.

€2,400

per pathway

€400

per factor

Contents

Split panel

ADDED

Argument left, proof right, inside one panel. Half a page of checklist under a heading reads as filler; beside the heading it reads as substantiation.

Enterprise agreements

Bespoke licensing and commercial terms tailored to the scale and governance requirements of your organisation.

Typical engagements start at €80,000 per year

Dedicated curation capacity

Custom agreement terms

On-premise or private cloud

Named scientific contact

Multi-year pricing

Procurement and security review support

Contents

Split accordion

ADDED

The heading stays put on the left while the accordion runs down the right. A full-width accordion wastes the measure — the trigger line is short and the rest of the row is empty.

Licensing questions

The four asked most often before a first conversation.

The full database for the licensed products, every release published during the term, and the tools that ship with them.

Yes. The controlled licence covers on-premise and private-cloud deployment.

Derived-data rights are set out per licence model and reviewed before signing.

Yes, with pricing fixed for the term.

Contents

Testimonial card

ADDED

Quote, rating, attribution. Unicode stars rather than an icon font — they inherit colour, need no icon attribute and cannot silently fail. Note the site’s own testimonials are still drafts and hidden, so this ships empty until copy exists.

The curation depth is the reason we license it. Public sets gave us candidates; this gives us mechanism we can defend in review.

★★★★★

Translational research lead

Top-20 pharma

We stopped maintaining our own regulatory graph the quarter after we licensed TRANSFAC. It was never going to be as complete.

★★★★★

Head of computational biology

Biotech, Series C

One engagement replaced five tools and four vendors, and the answer arrived with its provenance attached.

★★★★★

Director of discovery

Mid-cap pharma

Contents

Logo wall

ADDED

A centred claim over a row of marks. The bare strip already existed; this is the framed version, where the sentence above does the persuading and the logos are the evidence.

Licensed by research groups at 230+ institutions worldwide

Gx Icon Transfac V2
Gx Icon Transpath V2
Gx Icon Humanpsd V2
Gx Icon Platform V2
Gx Icon Genome Enhancer V2

Contents

Group · 2 components

Native blocks

Kadence ships blocks this library had been rebuilding by hand. Wrapping the real ones means fewer nodes, editing in the GUI afterwards, and behaviour that generated markup cannot express.

Icon list

FOUND

The site’s most-used block by a wide margin — 436 lists holding 2,836 items — and this library was approximating it with headings. The real block sets one icon for the whole list instead of one per row, and stays editable.

  • Full database dump under licence
  • Quarterly release with change notes
  • Named curation contact
  • On-premise deployment supported

Contents

Tabs

FOUND

Used on the product pages, absent from this library until now. Worth wrapping rather than faking: tab switching is behaviour, and an accordion is the only substitute — but an accordion reads as a list, not as alternatives.

Transcription factors, binding sites and PWMs, plus the geneXplain platform.

  • TRANSFAC® 2026.1
  • geneXplain® platform 7.8

Everything in Basic, plus signal transduction and the Pathway Omics Suite.

  • TRANSPATH® 2026.1
  • Pathway Omics Suite 3.8

Everything in Pathways, plus disease, drug and trial annotation.

  • HumanPSD™ 2026.1
  • Genome Enhancer 3.8

Contents

Group · 5 components

Articles

Eighteen blog posts exist and the library had nothing behind any of them.

Article header

ADDED

Posts currently open with a bare heading. Category, date and reading time are what a reader uses to decide whether to start at all.

Regulatory genomics

Why gene signatures fail in another cohort

A signature that survives cross-validation can still collapse on an independent dataset. The reason is usually not the statistics.

Prof. Dr. Alexander Kel  ·  12 June 2026  ·  9 min read

Contents

Post card

ADDED

A listing entry with its metadata. The media card has no category, date or author, which is most of what makes a list of posts scannable.

Regulatory genomics

Why gene signatures fail in another cohort

Cross-validation is not external validation, and the gap between them is mechanism.

12 June 2026 · 9 min read

Method

ATAC-seq and the enhancer problem

Open chromatin tells you where to look. It does not tell you what binds.

28 May 2026 · 7 min read

Case study

Master regulators in triple-negative breast cancer

Walking upstream from differential expression to the factors that explain it.

14 May 2026 · 11 min read

Contents

Author bio

ADDED

Who wrote this and why they are worth reading. On a scientific site the author is part of the evidence, and no post carries one today.

Dr. Alexander Kel CEO And CSO
Written by

Prof. Dr. Alexander Kel

CEO & CSO, co-author of TRANSFAC®

Has worked on transcriptional regulation since 1988 and co-authored the original TRANSFAC release.

All posts by this author

Contents

Figure

ADDED

An image that says what it shows and where it came from. Posts embed images bare today, which on a scientific site loses the provenance.

Gx Icon Humanpsd V2

Disease vicinity network for hypertrophic cardiomyopathy, re-inferred from updated HumanPSD curation.

Source: HumanPSD™ 2026.1

Contents

Pagination

ADDED

Previous and next cover an ordered series; a listing needs numbers, so a reader can tell how much there is and jump.

Contents

Group · 4 components

Publications and events

Two page types the site has and the library did not.

Publication entry

ADDED

The publications page is 452 headings and 117 rowlayouts, every entry assembled by hand. Authors first, title second, venue third is the order a researcher scans in, and it never varies.

Kel A.E., Gössling E., Reuter I., Cheremushkin E., Kel-Margoulis O.V., Wingender E.

MATCH: a tool for searching transcription factor binding sites in DNA sequences

Nucleic Acids Research  ·  2003

Waleev T., Shtokalo D., Konovalova T., Voss N., Cheremushkin E., Kel A.E.

Composite Module Analyst: identification of transcription factor binding site combinations using genetic algorithm

Nucleic Acids Research  ·  2006

Koschmann J., Bhar A., Stegmaier P., Kel A.E., Wingender E.

Upstream analysis: an integrated promoter-pathway analysis approach to causal interpretation of microarray data

Microarrays  ·  2015

Contents

Event card

ADDED

Six webinar pages exist and none of them has a reusable card. The date is the first thing a reader looks for, so it leads.

9 July 2026 · 15:00 CET

Release 2026.1 new features overview

Prof. Dr. Alexander Kel

A walk through the new SELEX-derived PWMs and the weighted-correlation composite module method.

Upcoming

Register

14 March 2026 · recorded

Upstream analysis from RNA-seq to master regulators

Dr. Philip Stegmaier

The full pipeline demonstrated end to end on a public glioblastoma dataset.

Recording

Watch recording

Contents

Schedule rows

ADDED

The webinar page builds its agenda as a 25-row table — exactly the case the table rule says to avoid: two columns, short values, and a scroll region on mobile the keyboard cannot reach.

15:00

Welcome and release overview

15:10

New in TRANSFAC 2026.1: CAP-SELEX and HT-SELEX matrices

15:35

Composite modules on a continuous signal — live demo

16:00

TRANSPATH and the Protein Genome Map update

16:20

Questions

Contents

Empty state

ADDED

What a search with no hits, a filtered list with nothing left, or a 404 should show. Today such a page falls back to the theme default, which says nothing and offers nowhere to go.

Try widening the year range, or clear the filters to see all 214 entries.

Clear filters

Contents

Group · 5 components

Behaviour

Blocks that do something when clicked. Each is wrapped rather than imitated, because behaviour cannot be expressed as generated markup — and because Kadence already emits the ARIA that hand-rolled versions get wrong.

Modal

FOUND

A real popup, and it does work from generated markup. The mechanism is indirection: the dialog sits on the page hidden with an id, and any link pointing at that id opens it. So the trigger is an ordinary anchor and knows nothing about dialogs beyond carrying the class the script binds to. Click the button below.

Contents

Video popup

FOUND

Click-to-play in a lightbox, used 52 times on the site. A raw embed loads the player and its third-party scripts on every page view; the popup loads nothing until someone asks for it.

Contents

Disclosure

FOUND

One long thing that starts collapsed behind a fade. Lighter than an accordion, which announces itself as a list of choices — use this where there is a single passage most readers will skip.

The Composite Module Analyst finds combinations of transcription factor binding sites whose collective strength correlates with a continuous experimental signal. Each promoter receives a composite score computed by weighted rank correlation, which is robust to outliers. Candidate models are then optimised with a genetic algorithm, where model fitness is correlation strength minus a complexity penalty plus an optional bonus for known factor interactions.

The output is a promoter-level table ranked by composite model score, with genome browser links, per-promoter binding site models, a graphical representation, a scatter plot of signal against score, model statistics, and a JSON representation for programmatic reuse.

Contents

Countdown

FOUND

Used on the launch pages. Needs both the ISO string and the epoch milliseconds — Kadence renders from the timestamp and edits from the string, and if they disagree the editor shows a different date than the visitor does.

Contents

Group · 6 components

From the reference systems

Compared against GOV.UK, Shopify Polaris, Atlassian and GitHub Primer. All four are application systems, so most of what they hold — form inputs, skeletons, drag and drop — has no place here. These appear in three or four of them and answer something this site actually does.

Banner

ADDED

Page-level strip. Every one of the four has it and this library did not. Distinct from a notice: a notice annotates a passage, a banner speaks about the whole page — ‘this is a draft’, ‘a newer release exists’. The release pages need exactly that, being a cycle stale.

Release 2026.2 is now available. This page documents the previous cycle.

This page is a working draft and has not been reviewed.

Page header

ADDED

Atlassian and Primer both carry one; utility pages here open with a bare H1. Trail, title, one line of context, and the actions belonging to the page rather than to any section of it.

HomePublications2026

Publications and patents

Peer-reviewed work by the geneXplain team and by groups licensing TRANSFAC, TRANSPATH and HumanPSD.

214 entries · updated June 2026

Code

ADDED

Identifiers set apart from prose. Atlassian and Primer both carry it, and a bioinformatics site needs it more than either: the 2026.1 notes alone contain factor_pairs_capselex, GSE59612, BDGP6.54 and GRCm39. Set in running text they look like typos.

A new MATCH™ profile set, factor_pairs_capselex, makes the heterodimer matrices searchable in the platform. The demo project ships with GSE59612.

Analyses → Galaxy → Single cell RNA-seq to DEGs → Find DEGs in single cell data

Contents

Glossary term

ADDED

A term that explains itself on hover and on focus. Three of the four reference systems carry a tooltip; Kadence has no such block, so this uses native <abbr title> — no JavaScript, works on keyboard focus, read out by screen readers. On a site where every other noun is an abbreviation it earns its place. Hover the underlined terms.

The database holds PWMs for animals, plants and fungi, together with experimentally verified TFBS and curated PTM annotation.

Contents

Progress steps

ADDED

Steps that know where you are. The static steps card says what the process is; this says how far along it runs, which is what a licensing or onboarding path needs.

Enquiry

NDA

3

Scoping

4

Quote

5

Agreement

Contents

Task list

ADDED

Rows that each carry a state. GOV.UK’s task list, and the shape a roadmap or a release checklist wants: what it is on the left, where it stands on the right.

TRANSFAC 2026.1 release notes

Published

TRANSPATH 2026.1 statistics

Published

Genome Enhancer 3.8 feature list

In review

Pathway Omics Suite 3.8 documentation

Not started

BioGRID attribution review

Blocked

Contents

Group · 3 components

Reference

Blocks for pages that document rather than persuade.

Timeline

ADDED

Dated entries down a rule. Built for the release hub, but publications, milestones and any changelog share the shape.

Release 2026.1

1,346 new SELEX-derived PWMs

Heterodimer binding specificities across 19 TFClass classes, plus a new MATCH profile set.

Read the announcement

Release 2025.2

Pathway Omics Suite and Protein Genome Map

An end-to-end multi-omics workflow, and a new database of genomic coordinates for protein features.

Read the announcement

Release 2025.1

Single-cell RNA-seq to DEGs

1,900 new transcription factor interactions and 98 integrated human pathways.

Read the announcement

Contents

FAQ accordion

FOUND

Questions that would otherwise bloat the page. startCollapsed, or the first pane opens on load and the section looks broken.

Licences run annually and include every release published in the term.

Yes. The controlled licence covers on-premise deployment behind your firewall.

Mouse, rat, Drosophila and Arabidopsis ship with the standard release.

Contents

References

ADDED

Numbered citations. A site that publishes claims needs one consistent way to source them; today they are inline italics, or nothing at all.

References

1.

Waleev T. et al. Composite Module Analyst. Nucleic Acids Res. 2006;34:W541–5.

2.

Stark C. et al. BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 2006;34:D535–9.

3.

Oughtred R. et al. The BioGRID database. Protein Sci. 2021;30:187–200.

Contents

End

That is the system

75 components. Everything above is generated by the same functions a production page calls, so the catalog is its own proof that each one survives raw paste.

Back to contents