From Zebrafish to Precision Medicine:

Discovering Master Transcription Factors with TRANSFAC®

Q&A: Coffee break with TRANSFAC

December 17th, 6 PM CET

FREE online seminar

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Seminar Description

In this webinar Dr. Alexander Kel, the CEO and CSO of geneXplain GmbH, will provide a general introduction into epigenomics and will analyze ATAC-seq data of BPTF knockouts in Acute Myeloid Leukemia (AML) (GSE226670) and ChIP-seq and CUT&RUN data of FOXO1 knockouts in diffuse large B-cell lymphoma (DLBCL) (GSE254405) for enriched transcription factor binding sites, composite modules and upstream regulators, via combined promoter and pathway analysis with TRANSFAC master-regulators and Genome Enhancer. 

In this webinar Prof. Dr. Alexander Kel, the CEO and CSO of geneXplain GmbH, will demonstrate how TRANSFAC® and the tools included in the geneXplain platform enable the identification of key transcription factors in model organisms like zebrafish, bridging the gap between basic research and medical applications for drug discovery.

The following main topics will be in the focus of this webinar:

  • Prediction of transcription factor binding sites
  • Revelation of regulatory mechanisms
  • Understanding disease pathways
  • Advancement of drug discovery

What you will learn in this webseminar 

  • How to extract or upload model organism promoter sequences for analysis
  • How to select context-specific factor lists
  • How to annotate the selected promoters with TFBSs
  • How to filter the TFBS predictions

Seminar Schedule

The session will start on December 17th at 6 PM CET with a lecture from Prof. Dr. Alexander Kel (approx. 1 hour) and will be continued with a Q&A session addressing the questions coming from the attendees of the online event (up to 30 minutes).

Information resources

What You Get

  • 1 hour lecture on TFBS search in model organisms and further expansion of the obtained results to the field of precision medicine
  • 30 minutes interactive Q&A session addressing your questions
  • Time-unlimited access to the video record of the session
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The Lecturer

  • Alexander Kel received his Ph.D. in Bioinformatics, Molecular Biology and Genetics in 1990 and has has over 35 years of research experience in Bioinformatics
  • He studied at Novosibirsk State University, obtaining an M.S. in biology with a focus on mathematical biology in 1985
  • His work spans numerous bioinformatics branches (sequence analysis, gene recognition, promoter/enhancer analysis and prediction, prediction of RNA secondary structure, analysis of signal transduction pathways, identification of drug targets, systems biology and systems medicine)
  • He is the originator of the “fuzzy puzzle” concept for gene regulatory regions modeling
  • Developed “upstream analysis” for identifying biomarkers and drug targets in various diseases
  • Participated in over 20 national and international research projects
  • Author of more than 130 scientific publications and several book chapters on bioinformatics and systems biology
  • CEO and CSO of geneXplain GmbH, Wolfenbüttel, Germany
  • Visiting Professor at Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland

Prerequisites

Basic knowledge of biochemistry and molecular biology. No programming skills are required.

Previous webseminar on model organisms

To Whom It Might Be Interesting

  • Biologists and bioinformaticians working with model organisms
  • Biologists, bioinformaticians, or medical researchers working in the area of precision medicine
  • Students interested in gene regulation aspects

FAQ

That’s ok! All registered course attendees will receive access to the video record of the session together with the presentation materials. 

You can ask your questions live during the online event using the Q&A section of the online webinar, or you can send us your questions in advance using the form on this page and Prof. Dr. Alexander Kel will address them at the online event.

Sure! All duly licensed users will be able to repeat all steps of the analysis that will be shown by Prof. Dr. Alexander Kel during the online event using their TRANSFAC full package accounts.

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